Buenos Aires 02 de Noviembre del 2020
Miller, KK (Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital - USA).
J Clin Endocrinol Metab. 2011 Oct;96(10):2939-49.
Anorexia nervosa is a primary psychiatric disorder with serious endocrine consequences, including dysregulation
of the gonadal, adrenal, and GH axes, and severe bone loss.
Reviews recent advances in the understanding of the endocrine dysregulation observed in thisstate of chronic
starvation, as well as the mechanisms underlying the disease itself.
Recent studies have provided insights into the mechanisms underlying endocrine dysregulation in states of chronic
starvation as well as the etiology of anorexia nervosa itself.
This includes a more complex understanding of the pathophysiologic bases of hypogonadism, hypercortisolemia,
GH resistance, appetite regulation, and bone loss. Nevertheless, the etiology of the disease remains largely
unknown, and effective therapies for the endocrine complications and for the disease itself are lacking.
Despite significant progress in the field, further research is needed to elucidate the mechanisms underlying the
development of anorexia nervosa and its endocrine complications. Such investigations promise to yield important
advances in the therapeutic approach to this disease as well as to the understanding of the regulation of endocrine
function, skeletal biology, and appetite regulation.