LABORATORIO DE URGENCIAS

Anorexia Nerviosa 

                                               
                     Miller, KK (Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital - USA).  

                                          J Clin Endocrinol Metab. 2011 Oct;96(10):2939-49.

Anorexia nervosa is a primary psychiatric disorder with serious endocrine consequences, including dysregulation 

of the gonadal, adrenal, and GH axes, and severe bone loss. 

Reviews recent advances in the understanding of the endocrine dysregulation observed in thisstate of chronic  

starvation, as well as the mechanisms underlying the disease itself. 

Recent studies have provided insights into the mechanisms underlying endocrine dysregulation in states of chronic 

starvation as well as the etiology  of anorexia nervosa itself.  

This includes a more complex understanding of the pathophysiologic bases of hypogonadism, hypercortisolemia, 

GH resistance, appetite regulation, and bone loss. Nevertheless, the etiology of the disease remains largely 

unknown, and effective therapies for the endocrine complications and for the disease itself are lacking. 

Despite significant progress in the field, further research is needed to elucidate the mechanisms underlying the 

development of anorexia nervosa and its endocrine complications. Such investigations promise to yield important 

advances in the therapeutic approach to this disease as well as to the understanding of the regulation of endocrine 

function, skeletal biology, and appetite regulation.